Mitochondrial Gene Study On Mice Has Revealed Possible Links To Memory

Mitochondrial Gene Study on Mice Has Revealed Possible Links to Memory

Researchers used mitochondrial gene editing to model genetic disorders in mice. While previous attempts have been made, in-depth phenotypic changes resulting from mitochondrial gene knockout, for example the alterations in observable characteristics when a specific gene is inactivated, remain largely undocumented. So, researchers used a programmable DNA base editing technology to analyze the genotypic and phenotypic impacts of knocking out the ND5 mitochondrial gene, and they found profound impacts on brain function, metabolism, and thermoregulation. They employed a specialized DNA editing tool to induce mutations in the ND5 mitochondrial gene, disrupting energy production and causing learning deficits, hippocampal atrophy, and obesity. I just found this incredibly fascinating as this is the closest we've gotten to documenting when a gene is inactivated like that.

More Posts from Imitative-magpie and Others

3 months ago

"do you guys have a fear of being seen? đŸ„ș"

*goes on to vividly describe an autistic meltdown* lmao I can't with you jules

I apologize– I really don't know what came over me last night, and rereading the sloppy tangent that I went on makes me feel sick. My mother would always say things like, ‘I'm too old to be pulling stunts like this’ and I guess somehow still, it's not enough to deter me from whatever this is. This blog should be a place for researching my possible sources and putting the questionnaire into use for those who reach out, in order to properly apologize to the victims that I keep having memories of, not whatever my emotional hang ups are. I promise that I will conduct myself in a more professional manner from here on out.


Tags
1 month ago

Yeah I have a suggestion for you

Are you a paranoid schitsophrenic?

Here's a word of advice, Anon. At least learn how to spell 'Schizophrenic' before you send a hate post. My schedule is very busy so I hardly have the time to respond to mindless ramblings of the illiterate.

1 month ago

peeks head in here

how's things going? haven't heard from you in a bit.

hope you're ok and making progress on your kin journey!

-the neon attic

Thank you for checking in on me, Neon Attic. I appreciate the message. In truth, I may have found myself a bit confused as of lately, and accidently made a kinfirmation announcement which may have turned out to be false.. Again. Now that it’s brought up however, I would like to make an invitation to any of the following fictionkin or fictives;

*Anyone from the source The Mandela Catalogue, especially the alternates

*Anyone from the Everyman HYBRID source

*Those who are from Marble Hornets

*Anyone from The Magnus Archives, but Especially any Jons or Elias’’

Some of my questions will pertain to dynamics and relationships in the sources, the more traumatic experiences within your source, and possible mental/phantom shifts you've experienced in relation to your identity. I feel I could probably gain a great deal of insight from these sources specifically at the moment, so if you are interested in reaching out, please answer this kincall. My dms are always open.


Tags
4 months ago

Remember how I said the copypasta was stupid.? I spoke too soon I think, I feel a tad off in headspace

Yeah Sorry If It's Out Of Your Style

yeah sorry if it's out of your style

Huh.


Tags
2 months ago

While I have the time to keep up on my blog maintenance, let's update this while we're at it;

*Boyfriend to Death (Completed)

*Everyman HYBRID (Completed and Revised, Possible Match) 

*Marble Hornets (Completed and Revised)

*Tribe Twelve (Completed and Revised, Possible Match)

*Identity V (Completed, Possible Match)

*The Coffin of Andy and Leyley (Completed, Mayyybee??)

*P.T (Completed and Revised)

*Madness Combat (Completed)

*Diabolik Lovers (Completed)

*Insidious (Completed and Revised, Possible Match)

*The Black Tapes

*Malevolent 

*Smile (Completed and Revised, Possible Match)

*Hazbin Hotel (Completed)

The Complete List Of Kinsidering Sources

Thanks to the help of so many of you both here on Tumblr, and on various discord servers, I was able to lay a lot of groundwork into discovering my identity. I would like to share a list of sources I have been given and am currently looking into in order to widen my sample size regarding memories as a whole. Here is where I currently am in this process;

*The Dream SMP (Completed)

*Mouth Washing (Even Though I Have Mostly Ruled That Out) ((Completed.. obviously))

*Homestuck (Not Really Completed But I Feel I've Seen Enough)

*A Song of Ice and Fire (Completed and Revised)

*Maximum Ride Series (Completed and Revised)

*Final Destination (Completed and Revised)

*Madoka Magica (Completed)

*Supernatural (Completed and Revised, Possible Match)

*Zero Escape Series (Completed)

*The Magnus Archives 

*SCP and Related Works (Completed and Revised, Possible Match)

*Death Note (Completed and Revised, Possible Match)

*Arcane (Completed and Revised)

*The Magicians 

*Ave Mujica

*The Mandela Catalogue (Completed, Possible Match)

*Devilman Crybaby 

*American Horror Story (Completed and Revised)

*The Omen (Completed and Revised, Possible Match)

If anyone from these sources would like to impart any insight or simply share any memories that have been weighing on them..

Well, you know I'll always be listening.


Tags
3 months ago

hi jules !!! i hope youre doing okay <3

i was just thinking about your Kin Search and a source or two popped into my head that felt like they could possibly be a match for you!! so if you’re still looking for sources to check out, i would Definitely recommend EverymanHYBRID + TribeTwelve and Marble Hornets!! I tried to check to see if these were mentioned on your blog somewhere to see if youve looked into them, but im at work so im a bit limited in my research abilities rn :’) theyre all actually YouTube ARG series!! theyre a bit funky and hard to follow tbh, so i have some really great analysis/explanation videos saved on hand if youd like to see those!!! feel free to message me if you wanna discuss them a bit <3

Thank you so much for reaching out to me. In truth, I’ve actually been looking into this source recently so it is a funny coincidence that you happened to send the ask at this moment. I appreciate it though, Everyman HYBRID definitely holds a special place in my heart, and the themes of a repeating timeline or script, along with the heavy themes of being watched in these sources stood out to me significantly. There are a few sources I have not yet added to my list yet because they have either been suggested since the date I posted, or I have not yet viewed and/or revised notes on said sources, so I am currently in the middle of a second viewing of Everyman HYBRID and Marble Hornets. I would absolutely love to discuss the series more in depth with you, at your earliest convenience, of course.


Tags
4 months ago

Recovery has been a bit difficult. I worry that with each time that my body breaks down and develops more issues, it becomes harder for people to overlook and I become more difficult to love- which I know of course when I write it down that it's a terribly stupid, and ableist thought.

I would never think such things about someone else in my position, but when I haven't put words to that gut feeling and it only has to be directed inwards I worry about it on a near visceral level. It keeps me awake at night. Nobody could love what I've gone and become. This is too much for anybody. I'm even too much maintenance for myself


Tags
2 months ago

damn, still no TMA on the kinsidering list? ;P - steph

Ah, you've noticed I don't have it categorized under complete, revised and/or a possible match. I understand why this might come as a surprise given the high number of source suggestions for this particular media, so maybe this might be a good time to break down my method in categorizing and researching different sources.

In order for me to feel comfortable organizing it under any one group, I try to at the very least get through at least one full watch through, read through, et cetera. From there, I will mark the source as completed, and look over the notes I have taken on what felt familiar to me or stood out. 

This is where I revise my notes and go through a second watch through comparing my previous notes with what I have written about my own experiences. Then and only then, will I categorize a source revised, or even possible match. Of course there are outliers to this method. Namely a certain famously long webcomic I had to make a special exemption for this rule. 

That being said, The Magnus Archives is still uncategorized in my source list because while I have gotten to know a couple of wonderful fictionkin/fictives from said source, I regret to say that I have not yet viewed the content. I do plan to remedy this however, in short time. 


Tags
1 month ago

A Dream About A Kindled Flame

He’s rough, glaring at me with brown eyes that are tawny and sharp. The burns encompass his entire being, his nose crooked and scarred, his neck licked by intricate scarring as he lays there, waiting for me. I won’t bore you with the details- we all know how this goes. 

The story really begins in a bar. My name is Jim Navy, and I’m a wanted man. There’s just so many criminals in downtown Chicago, I never stood out, and so I was never caught for my heinous actions. So long as you keep your head down, you can live as a ghost during the day and a monster during the night. I remember when I was young and romanticised this lifestyle, how I thought that it would grant me respect and protection, but these people out here are nothing more but rabid dogs, willing to throw you under the bus for a moment's notice. I found no loyalty in Chicago, but I made sure I always came out on top. Whether it be a crook trying to con me, or a late night lover threatening to go to the cops, I got my last word in. There was nothing more to it than that.

‘Sometimes I still think about her face, after I cut her throat.’ This was the thought in his mind that allowed me to disconnect from him in the dream. As he remembered the woman he killed and mugged, I too could feel her face burning the backs of my eyes. ‘This man is a monster,’ and still he takes a long fluid swig off his beer. He’s haunted by the actions he took that night, is how he tries to ration it with himself, but it doesn’t stop him from sauntering over to the pretty redhead who's been staring him down across the bar since the moment he walked in and making the same mistakes he did that night. She’s so pretty though, you can’t hold him accountable for his actions when the woman looks like that, right? Is what he tells himself, and I find myself wanting to gag.

He is right though, she is beautiful. Long dark red hair that's impossibly straight, and wild amber eyes. She smirks as he takes a seat across from her at her table, and purrs out a simple, “Took you long enough,” and from there, he drunkenly stumbles into the same mistakes. Sharing too much, asking to take her back to his place, telling her all the things he expects will happen should she go home with him, and she’s all smiles in agreement, but since I’m not Jim, I can see the steady calculation in her eyes. This is a trap where the hunter will soon find out he’s prey. 

She pushes me against the wall in a passionate kiss, trapping my arms above my head in a pose that leaves all my vital organs open for attack. It’s passionate, and I can feel the heat sweltering around us in the back alley. There’s something chemical fueled in her perfume that’s making me dizzy. It permeates the cool night air along with the heat that exudes off our bodies. 

This girl is taking over.

I never got this sort of attention before, not really. It’s rare that attractive women pay me any mind, so my head is still floating when she roughly sinks her hand into the back pocket of Jim, and fishes out his wallet. It’s then that she abruptly pulls away, looking through the mementos of drivers licences he keeps, of all his victims. “What’re you doing, angel face?” He slurs, making a reach for hands. “If you’re smart, you’ll stay the hell back.” The charm has been forgone, and her voice is hot with venom. “How many people have you killed?”

“What the fuck?” His voice is slurred as sweat drips down his temple. The heat comes off of her in waves, like when you first open an oven on a cold winter night. You can see the steam, as she begins to ignite, flames fragmenting off her frame. 

“Wait!” She pauses when it’s my voice that comes through, and not Jim’s. This isn’t how the story goes, afterall. Curiously, the fire engulfed entity that now stands before me cocks her head to the side.. Imploring me to continue. “Does your abnormally high body temperature have any any affect on your neurological function? Because I read-” She cuts men off with a stunned cackle, and in the absurdity of the situation, I can’t help but timidly join her laughter. After all, it’s not every day that you find yourself about to be killed by the human torch. 

Set me ablaze, she did. It was horrific, the fire crackling and searing away layers of flesh. I desperately grabbed at her, only to find her body the consistency of half melted wax. A cruel and horrible death, but I found myself wishing I hadn’t wasted my question on something so stupid.. I was intrigued by her.


Tags
2 months ago

Please Share What's Given You Mental/Phantom Shifts

We all know that feeling- where you're watching a movie, and something on screen catches your attention because it's just like you. That creature transformation, that dynamic between two people, that mythical beast.. whatever it is, we latch onto these scenes because they help us better contextualize and explain our experience as alterhumans, because it so deeply affects us, leaving us in shifts for days after. 

I would like to share a few moments in media, besides the suggestions of others, that have impacted me in such a way.

I'd like to start by sharing my thoughts regarding the movie The Omen. It's one of those horror movies that stick with you, not just because of the plot but the intrigue surrounding such a film. Everyone knows that rumor that it's a cursed film due to the tragic occurrences that surrounded it's production. In the series of films, horrible things happen to anyone who gets close to Damien, as if he himself has willed them to happen. He's depicted as the antichrist, and the way he talks, the things that happen in the trilogy.. Well, it just left me feeling like we're in the same boat. That there's something more to it, because I feel stained by something horrific and I feel as though I've inflicted this malcontent against anyone who gets close to me. 

Please Share What's Given You Mental/Phantom Shifts

It's part of why Insidious spoke to me as much as it had, my first watch through. The demons and spirits in Insidious are described as hungry and they can even smell the still living souls when they astral project from their bodies at night. They feed off the fear of those they afflict, and they aim to steal the bodies of the dreamers for their own. That scene where there was that dark figure standing in the corner of Dalton’s room? That is so close to how I've found myself in my many dreams, haunting others like a sleep apparition demon. I would be lying if I said that was my only reason though
 The red door that's been shown in the original film– I heard they're making a movie giving it some background story, but there's something about the red door that felt familiar. I don't even know why. 

Please Share What's Given You Mental/Phantom Shifts

The Rake had been one of the creepypastas of the early 2000s that had stuck with me throughout my childhood- I remember a depiction of its ghoul like figure, sitting at the edge of beds. If you look directly at this creature, it attacks viscously, wishing not to be perceived. This shrill voiced anomaly of the woods reminds me much of myself, reminds me of things I’ve long forgotten. The Rake holds a special place in my heart. I was nearly obsessed with the story in my preteens, and it remains a topic of interest to this day, along with the stories of The Operator. 

Please Share What's Given You Mental/Phantom Shifts

It should come as no surprise that I relate a fair bit to Johnny Truant, with his descent into paranoia and hysteria throughout his journal, and his ambiguous end. It’s just one of the many reasons I felt so attached to House of Leaves. This character is not my only reasoning for why I feel attached to House of Leaves though. There are recurring themes that have left its mark on me, and made me who I am. The house’s inner dimensions being as twisted and foreboding as they are, as well Will’s letter regarding the house to Karen had left a significant impact on me. It’s so unfortunate that only fragmented pieces seem familiar to me while not touching on some of the topics of my dream memories- because I would claim this as my source in a heartbeat. 

Smile was an interesting one, to give me Kin shifts. While Insidious was the first movie to allow me kinshifts that left me truly feeling like a monster, Smile was the first time I found I liked it, and how that terrified me. The idea of something so horrific infecting someone in a parasitic nature–

I have always felt my urges held those same parasitic traits. It only got worse with the sequel. The opening soundtrack and the ending left a terrified thrill in my heart, left me feeling that desire to suck the marrow straight from fear itself. 

Please Share What's Given You Mental/Phantom Shifts

.. And then there was ‘The Murders of Molly Southbourne’, a book that I still reflect on not for it’s literary prowess, as I found myself not particularly enthused by the lackluster route the book had taken.. But the very first moment the story’s central theme was unveiled to me, the idea of what could be had always sat heavy in my head. Stories of doppelgangers, and monsters being born from shed blood had always been something that caught my eye, and this book was no different. Sure, there were other stories such as Plastic Faces, taken straight from r/No Sleep, and Tender is the Flesh with the dehumanisation of Jasmine and heavy themes of gore. I guess in truth, the visuals in my head have always drawn me in, fed life to me where I would otherwise be vacant. I just want to know who I am, maybe that's why the theme of doppelgangers and the uncanny has always caught my attention so consistently.    

There are others like this that I ruminate over, trying to find meaning in while it turns a blade of desire deep in my soul,

But I’m interested in you. What do you remember viewing, that first ever gave you those ‘shifty feelings’? Feel free to reblog with your own experiences.


Tags
Loading...
End of content
No more pages to load
  • apocalypticautumn
    apocalypticautumn liked this · 5 months ago
  • imitative-magpie
    imitative-magpie reblogged this · 5 months ago

_I Want to Know Your Phobia_ Name:Jules Age:24

148 posts

Explore Tumblr Blog
Search Through Tumblr Tags