Vaccine Infographic by Leon Farrant.
I often speak with patients who tell me that they do not wish to be vaccinated because they do not see the point, that it is a farce, that it can cause autism (it does not), despite educating and informing them of the reasons behind it.
In the same way that people who did not grow up during the great wars of the mid-twentieth century have little frame of reference as to what the toll of total war can be, neither can a newer generation of people who have never seen the effects of polio, smallpox, and measles ravage humanity. For many people in the developed world, these are just distant, faded memories captured in the pages of medical textbooks.
I sincerely hope that the understanding of why we vaccinate does not become lost over time, that people need not fall victim to these preventable diseases; otherwise, the suffering, the challenges, and the research that went into developing these vaccines were all for nothing.
Recognising silent acute pain in animals - assorted species grimace scales:
Development of the Horse Grimace Scale (HGS) as a Pain Assessment Tool in Horses Undergoing Routine Castration
The composition and initial evaluation of a grimace scale in ferrets after surgical implantation of a telemetry probe
The Assessment of Facial Expressions in Piglets Undergoing Tail Docking and Castration: Toward the Development of the Piglet Grimace Scale
The Sheep Grimace Scale as an indicator of post-operative distress and pain in laboratory sheep and the Coding and quantification of a facial expression for pain in lambs
Mouse - How to be a pain management advocate for exotic and zoo animals (full text available - includes additional species)
The Rat Grimace Scale: A partially automated method for quantifying pain in the laboratory rat via facial expressions
Evaluation of EMLA Cream for Preventing Pain during Tattooing of Rabbits: Changes in Physiological, Behavioural and Facial Expression Responses
Pain evaluation in dairy cattle
Pain is subtle - we cannot depend on vocalisations or extreme abnormal behaviour to determine if an animal is on pain - animals can cover up pain while going about their daily life. Grimace scales have been found to be reliable indicators of pain (full text available)
Unfortunately, I could not find a clear visual grimace scale for dogs, cats or birds :(
Which is a shame, because perhaps I could have recognised my own dog’s discomfort for the acute pain it was sooner:
(left: dog in pain. See eyes, tension, cheeks, whiskers, ears compared to the multiple species grimace charts above. right: tired but not in pain dog)
Perhaps my new books that arrived today might have some on dogs at least. There’s this visual blog post of a stressed dog at the vet - stress in the absence of a trigger looks very much like pain.
Here is a small comparative cats, with the link going into more detail. Not a scale but better than nothing:
Bonus round - you can get free A3 posters on recognising pain for Rabbits, Mice and Rats from the National Centre for the Replacement, Refinement and Reduction of Animals in Research. My rabbit specialist vet has the rabbit one!
Me whenever I see a corporate ad trying to say “we’re all in this together”:
Microbiologists have learned how a probiotic bacterium used to treat irritable bowel syndrome can soothe gut bacterial infections caused by salmonella, paving the way for potential relief from foodborne illnesses that affect millions of people annually.
Augochlora pura (Pure Green Augochlora) | Feb 2019 | copics, micron pen, colored pencils
protestants: god is not an absent father! talk to god like a friend! god is always with you! bring your problems to god, no matter how small! it’s not at all weird to call god “daddy!”
catholics: god is far too important to give a fuck about your lost keys or your algebra exam. please address your petty concerns to one of god’s ten thousand holy secretaries. if it’s really important, consider asking his mom.
Colonial rotifers showing eyespots and corona, magnification 200x - 500x. Ralph Grimm.
(Image: U. Müeller)
New neurons (in green) are guided to the neocortex - responsible for controlling language and movement - not by glial cells, but by a protein called reelin.
Journal reference: Neuron, DOI: 10.1016/j.neuron.2011.01.003
Aspirate of a mammary mass from a 8 year-old, female-intact, Yorkshire Terrier. The patient was found wondering in a field by a good Samaritan-turned-owner over the 4th of July weekend. Although she was acting normally, the owner brought the little dog in for a ‘look over.’ On physical examination a 2cm mass was felt in the left mammary chain. No obvious spay scar was present.
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On cytology there were copious clusters of epithelial cells. These epithelial cells (top picture) were very non-descript, making for large, jumbled piles of cells. Notice how you cannot see any well-defined cell borders between them?? Just a ton of nuclei (and nucleoli) blending in together! That’s a sign of cell craziness! Many clusters were surrounded by this gorgeous, pink-magenta material. Likely secretory product or matrix.
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Cytologic diagnosis: Mammary tumor! Although the cells look quite malignant on cytology, many studies have shown you cannot reliably determine malignancy with cytology alone. Thus, you NEED a biopsy to determine if a mammary tumor is malignant or benign in a dog. And flip a coin on that - about 50% are malignant and 50% are benign. Intact female dogs have an almost 35% lifetime chance of developing one of these beasts!
An assortment of scientific things from the wonderful world of biology
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